gabapentin withdrawal symptoms in dogs

Some of the most common side effects of NSAIDs in animals reported to FDAs Center for Veterinary Medicine are: Vomiting; Decreased to no appetite; Decreased activity level; and. So it's not something that we typically have many problems with. Will my dog experience withdrawal symptoms when coming off gabapentin? If drowsiness doesnt go away after a couple of days, consult your vet about a dosage adjustment. The biggest benefit to us is not having financial concerns come into play when having to make tough decisions when it comes to medical care. This drug should not be stopped abruptly when used to treat seizures, as it can result in withdrawal seizures. The pain medication tramadol is starting to fall out of favor with veterinarians. Veterinary Secrets 2022 Bestie PawsLower Manhattan, New York, NY 10038, USA, Side Effects of Stopping Gabapentin in Dogs, FAQs about side effects of coming off gabapentin in dogs. No, it is not recommended to give your dog over-the-counter medication without consulting with a veterinarian. Gabapentin (brand names: Neurontin, Aclonium, Equipax, Gantin, Gabarone, Gralise, Neurostil, Progresse) is an anti-seizure and pain medication that is used with other medications to treat seizures and is also used to treat chronic pain, primarily nerve pain. Among the cases reported, gabapentin withdrawal symptoms typically peaked three days after someone's last dose. Hannah Elizabeth is an English animal behavior author, having written for several online publications. In veterinary medicine, Gabapentin is used off-label and in conjunction with other meds to prevent neuropathic, However, we know that Gabapentin inhibits the voltage-gated calcium channels in the brain. If you forget to give your pet a dosage, administer it as soon as you realize. This is because stopping gabapentin abruptly can lead to a number of side effects that can negatively impact your pets health. This is because human oral suspensions almost always use the artificial sweetener xylitol as a taste enhancer. The swelling occurs 30 minutes to a few hours after the exposure. Gabapentin is safe and efficient for dogs but only when used correctly and in individually tailored doses. What is the most common side effect of gabapentin? [The Harsh Truth]. An Expert Review, What's That Smell? So we'll start off with just what gabapentin is. Symptoms of gabapentin withdrawal may include nausea, dizziness, headaches, insomnia, and anxiety. CBD oil for dogs is a natural and holistic supplement that can help with the same specter of issues as Gabapentin. It has also shown to be beneficial when used in combination with otherpain medicationssuch as nonsteroidal anti-inflammatories or opioidsto help with pain associated with surgery. CBD oil can help to heal inflammation in the body. What is the recommended way to wean a dog off gabapentin? Innovet Pet does not necessarily share the opinions, views, or commentary of any testimonials on this site specifically because such views are strictly the views of the reviewer.Additionally, these testimonials are not intended to make or imply claims that these products can be used to diagnose, treat, cure, mitigate, or prevent any disease. Do not stop this medication abruptly in pets with epilepsy, as this can cause withdrawal seizures. 4. Do not hesitate to talk to your trusted vet if you think your dogs condition could benefit from Gabapentin. Your veterinarian may recommend providing gabapentin exclusively in the evening for a few days to allow your dog to acclimate. While it wont completely take away the problem, it can work to calm the CB1 and CB2 receptors in the brain that cause this horrible medical issue. who use gabapentin for seizures and stop taking it abruptly may suffer a resurgence in seizures or more frequent seizures. Continue with Recommended Cookies, The Honest Kitchen Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, CBD for Dog Anxiety: Top 11 Products According to a Veterinarian, The Best Probiotics For Dogs in 2022 According to a Veterinarian, The Best Cat Food for Indoor Cats: Our Top 7 Picks, CBD for Cat Anxiety: Our Top 5 Picks + Reviews, The Farmers Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, Ollie Dog Food Reviewed: Pros, Cons, and Ingredient Analysis, Open Farm Cat Food Reviewed: Pros, Cons, and Ingredient Analysis, By Katelyn Son | Updated February 22, 2023. Do not stop this medication abruptly in pets with epilepsy, as this can cause withdrawal seizures. If you accidentally miss a dose, you have two options: When discontinuing your epileptic dog from Gabapentin, do not stop the medication suddenly. Log in 24/7 to access your pets health care information. Another study in 2009 found gabapentin influences a receptor that helps create new synapses in the brain. Gabapentin is being prescribed more and more to dogs and cats for a number of reasons. Key Takeaway: Keppra is an anti-seizure drug for dogs, cats, and people. Some dogs might need to stay on certain medications to survive. Methods: The patient is an 81-year-old white female with a life-long history of schizoaffective disorder with bipolar type I tendencies who . Give the missed dose as soon as you remember and then the next scheduled dose (just do not double up the dose to compensate). For example, it is rarely used in pregnant or nursing animals because it can cause miscarriage and birth defects, and because it transfers . How much CBD oil is necessary to give my pet? Gabapentin is a prescription anticonvulsant used to treat epileptic seizures, postherpetic neuralgia, and restless legs syndrome. A dropper can help you to measure the drops better and even pinpoint the areas you need to drop it onto a bit easier. During prolonged use, phenobarbital in dogs can. We will also discuss the potential side effects and explain when it is time to notify the vet. These questions can help to start an important discussion about your dog and their CBD oil usage. Common side effects of gabapentin include mild lethargy, drowsiness, stumbling, incoordination and depression. How Long Does Gabapentin Sedation Last in Dogs? The most frequently reported side effects of gabapentin are sedation and ataxia. Although the medication mimics GABAs effects, its exact mechanism of action is poorly understood. To help you better understand these side effects, weve put together a list of FAQs about coming off gabapentin in dogs. This is a less traditional and relatively novel Gabapentin use in pets. Gabapentin is administered by mouth in the form of a capsule, tablet, or compounded liquid. Can gabapentin be stopped abruptly in dogs? Gabapentin is generally safe for dogs as long as dog parents follow guidelines and veterinary instructions. Yes, dogs can experience withdrawal symptoms when coming off gabapentin. Gabapentin is also used as a sedative at 30-60 mg/kg one to two hours before a stressful event, such as a vet appointment, on an as-needed basis. The above is a transcript taken from The Dr Alex Answers Show. Before giving your dog any medication, including oral gabapentin for pain relief, it is important to consult with your veterinarian. Please share your experiences and stories, your opinions and feedback about this blog, or what you've learned that you'd like to share with others. Namely, CBD oil can be used to manage seizures in dogs because of its antiepileptic features, pain due to its ability to block the pain pathways in the brain, and anxiety since it has anxiolytic effects. This makes it perfect to use on dogs who have extremely dry or irritated skin. Capsules and tablets should be stored at room temperature around 25C (77F), away from moisture. Your doctor may suggest increasing the dose frequency to every 8 to 12 hours as your dog adapts. Make sure to also include small doses of CBD oil so their body will still get important nutrients and relief. Side Effects of Cytopoint Injection for Dogs, What Are The Side Effects of Dogs Taking Steroids. However, physicians may prescribe medications for some of the more uncomfortable side effects of withdrawal. Instead, slowly decrease your pets dosage and frequency over a period of 2-3 weeks. By Be careful when administering liquid gabapentin to your pup, as it sometimes contains the sweetener xylitol, which is toxic for dogs. Sometimes a dog is too small to use the human formulations. This could include thembarkingmore often than they used too, being irritable, and many other similar issues. Also given how it's metabolized, theoretical care should be taken if a pet is in severe liver or kidney failure. Doses of 3600 mg/day have also been administered to a small number of patients for a relatively short duration, and have been well tolerated. All medications cause side effects some more and others less severe. This is because it tends to lose the anti-anxiety effect if gabapentin is given on a regular or long-term basis. Since it is a short-acting drug, the effects will be gone in 24 hours; however, the medication may last longer in dogs with renal or liver impairment. Gabapentin formulations are available in three different forms capsules, tablets, and compounded liquid. It's an anti-epileptic drug that also has painkilling properties and really it's used mainly to treat chronic pain. Dosages up to 2400 mg/day have been well tolerated in long-term clinical studies. Symptoms of gabapentin withdrawal may include nausea, dizziness, headaches, insomnia, and anxiety. A Guide to Deramaxx for Dogs: Benefits, Dosage, and More! We sincerely recommend using the Honest Paws CBD oil. This is especially important if your dog has already had an allergic reaction to something else, including food, dander, or grass, to name a few. When CBD oil is used, it can make your dogs blood pressure drop slightly. Yes! When used to treat seizures, this medicine should not be suddenly discontinued since it might cause withdrawal seizures. Some medications, such as NSAIDS, can be a problem and cause liver damage in dogs. CBD, which is an abbreviation for cannabidiol, is just one of the hundreds of cannabinoids found in cannabis plants. Gabapentin is excreted by the kidneys, so animals with kidney disease are more susceptible to effects of overdose. Gabapentin is an add-on medication that, when used in combination with other anti-seizure drugs, helps manage canine seizures and epilepsy. This is why it is important to gradually wean your pet off the medication under the guidance of a veterinarian. Some medicines can actually cause seizures. Namely, the slightly sedating effect can be used to relieve situational and generalized anxiety. How can I tell if my dog is experiencing side effects from coming off gabapentin? If your dog suffers from chronic pain or seizures, chances are you have heard about Gabapentin. The most common symptoms of gabapentin withdrawal are agitation, confusion, sweating, vomiting/diarrhea, tremors, high blood pressure and insomnia. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine. support the rigorous scientific medical research of marijuana (cannabis/hemp) - derived products. Skip the missed dose and give the next dose in accordance with the regular schedule (once again, do not give a higher dose as a form of retaliation). Sedatives for Dogs: How and When to Use Them Safely, How to Handle Aggression Between Dogs (Inter-Dog Aggressive Behavior). Can I give my dog over-the-counter medication to help with side effects from coming off gabapentin? Can I Use Wood from Outside for My Bearded Dragon? While gabapentin is generally considered safe when used as directed, long-term use can lead to a number of side effects, including liver and kidney damage. Therefore, do not ask the vet for a dosage modification before this timeframe. Get practical pet health tips, articles, and insights from our veterinary community delivered weekly to your inbox. Response and effectiveness. 8. If you just stop cold turkey, your dog could experience withdrawal symptoms, such a withdrawal induced seizures and rebound pain. Statements within these testimonials have not been clinically reviewed or evaluated by the FDA. Lets explain the most popular Gabapentin uses. Finally, we should note that Gabapentin is an add-on medication meaning it is usually used in conjunction with other drugs and rarely given on its own. Forbest pet CBD oil, the higher the price, the more likely it will provide ideal results. Gabapentin is a drug that was formally approved in 1993 for the treatment of epilepsy. Check the directions on the bottle or ask your vet if you are not sure of the correct dosage for your dog. Giving this medicine just before a meal is optimal. When used together with NSAIDs and opioids, it boosts their efficacy and allows lowering their doses. Gabapentin usually stays in a dogs system anywhere from 5-7 hours. Originally developed as an anticonvulsant (anti-seizure) medication for humans, like many human medications it is . It really treats a hypersensitivity to that pain. Canva Its important not to rush this because too much at once can be harmful. Follow the directions on the label for compounded liquid medications. Its that simple! clavacillin for dogs side effects; what does the last name hill mean. The abnormal movement can occur in the legs, the head, the torso, or all three. Gabapentin typically takes 1-2 hours to start working on dogs. A case of apparent gabapentin withdrawal symptoms after discontinuation of gabapentin therapy is reported. Gradual increases of the medication over time is recommended to alleviate these effects. Can gabapentin withdrawal be fatal in dogs? That said, the medication may last longer in dogs with renal or liver impairment. Medication can sometimes make your dog feel very tired andlethargic. If your pet has a sensitive tummy and is prone to vomiting and diarrhea when given meds on an empty stomach, give the Gabapentin dose before feeding. Can stopping gabapentin cause my dog to have seizures? Gabapentin is a medication that is used to treat seizures, chronic pain, and anxiety in dogs. Gabapentin is a human medication, and its use in veterinary medicine is off-label, meaning it is not FDA-approved for pets. It helps to build up the fatty-acids, like omega 6, in the skin which can help with hydration. On the other hand, you should ask the veterinarian about possible drug interactions, especially if your dog is on long-term medications for another condition. Always consult with a veterinarian before starting your dog on any additional medications or supplements that were not originally prescribed to ensure that they are safe with your dogs current medications. Therefore, Gabapentin should be used with caution in dogs with: On the other hand, Gabapentin should not be used at all in dogs: The general rule of the thumb is that dogs should receive around 5 mg of Gabapentin per kg of body weight every 12 hours. Gabapentin works to block certain signals in the brain, reducing a dogs capacity to experience pain. Gabapentin is generally dosed at 5-30 mg per kg of weight up to three times daily in dogs. These are individual experiences of real-life people who have administered our products to their pets. Because of this, make sure to discuss your concerns with your vet and come up with a plan that will work to help safely wean your dog off of their medication. For instance, youll find some dog treats that contain CBD oil in them. Always check with your veterinarian before weaning your dog off of any medication. One of the most common side effects of stopping gabapentin in dogs is agitation and anxiety. Besides Gabapentin, there are many other dog prescription medications available to treat seizures and provide veterinary pain management. An allergic reaction can happen immediately after dosing, or hours later, so you should always note when your dog has been given a medication or has had a vaccine. Summary: How to Wean Your Dog Off Gabapentin. However, first, you need to consult with your trusted veterinarian and get a prescription. Your dose of gabapentin may be tapered down over a period of a week to several months to reduce withdrawal symptoms and to avoid complications associated with stopping gabapentin rapidly. Postherpetic neuralgia is pain caused by shingles, which can last many months after having the illness. Uncovering the Pros & Cons! However, it is already becoming quite popular. The dose of gabapentin varies significantly, based on your dog's weight and the intended goal of the medication. This medication will take effect quickly, in about 1 to 2 hours, and improvement in clinical signs should follow. You may administer gabapentin to your pet with or without food, but if your pet vomits after taking it on an empty stomach, consider providing it with food or a reward in the future. Veterinarians will prescribe a starting dose, and if this results in the dog becoming a little too sedate, the veterinarian will taper the dose down to the most effective one. Gabapentin works best for managing neuropathic pain pain that stems from issues like extruded discs and nerve injuries. While pain reliever medications can be very helpful when it comes to combating many illnesses, they can sometimes cause more harm than good. The vet will help create the best plan for weaning your dog off in terms of decreased dose and administration frequency. If a specific form is easier for you to use or more acceptable for your dog, ask the veterinarian to prescribe it in particular. Peak concentrations of gabapentin (immediate-release) occur within 2 to 3 hours. Furthermore, dogs (or people!) In her free time, she acts as a foster parent for stray animals before their adoption, likes to read SF books and making salted caramel cookies. Gabapentin can be used to calm dogs during stressful situations such as grooming appointments, long car rides, veterinary clinic visits, loud events (fireworks, thunderstorms), etc. Some of the symptoms of gabapentin withdrawal are similar to those of alcohol withdrawal. Gabapentin is available in several forms that are human-labeled products: There is also an oral solution made at 250 mg/5 mL; however, sometimes the solution is formulated withxylitol, which is extremely toxic to dogs. What are the side effects my dog might have? Gabapentin can be a very helpful medication for dogs who suffer from pain and seizures. As an Amazon Associate, I earn from qualifying purchases. They might recommend you increase your dose or try a different method with the oil. We don't want to get carried away, and the more we give isn't going to increase necessarily its pain killing effects after a certain dose range. In certain severe cases, dogs may develop breathing problems, swelling of the face and/or muzzle, blue gums and/or tongue, or excessive drooling. This is not good as your dog needs water and the nutrients food provides for their body to survive. Gabapentin is available in pill, tablet, or liquid form. CBD oil will work to soothe the inflammation so your dogs body can get back to working normally again. When providing gabapentin to dogs who are already on morphine, phenobarbital, or potassium bromide, or are taking CBD oil, take caution. Gabapentin works by interacting with the brain and spinal cord. You can keep the questions listed above in mind when talking with them. The capsules and tablets come in various strengths 100 mg, 300 mg, and 400 mg, and the oral liquid contains 250 mg Gabapentin per 5 ml of suspension. However, they are individual results and results do vary. 7. While CBD is a safe thing to use, there are a few side effects youll need to be aware of. If your dog is experiencing side effects from coming off gabapentin, it is important to contact your veterinarian immediately. 4 In our experience, other possible side effects include gastrointestinal distress-such as loss of appetite, vomiting and diarrhea-and increased anxiety or agitation. Another common issue medication can cause in dogs is diarrhea. Some of it's broken down by the liver and is then removed from the body kind of exclusively by the kidneys. If you just stop cold turkey, your dog could experience withdrawal symptoms, such a withdrawal induced seizures and rebound pain. Gabapentin is an add-on medication that, when used in combination with other anti-seizure drugs, helps manage, pain that stems from issues like extruded discs and nerve injuries. Harm than good to use on dogs for humans, like many human medications it is important to contact veterinarian... The symptoms of gabapentin withdrawal may include nausea, dizziness, headaches,,... For your dog adapts # x27 ; s weight and the nutrients food provides their! To start working on dogs who suffer from pain and seizures is too small to use them,... We typically have many problems with consulting with a veterinarian check with your veterinarian before weaning your off! Discs and nerve injuries correct dosage for your dog off of any medication couple of days, your!, dogs can experience withdrawal symptoms typically peaked three days after someone & # ;! Including oral gabapentin for seizures and stop taking it abruptly may suffer a resurgence seizures... Help you better understand these side effects from coming off gabapentin, may! And improvement in clinical signs should follow anticonvulsant used to treat seizures, this medicine just a. Painkilling properties and really it 's not something that we typically have many with. Dog over-the-counter medication without consulting with a life-long history of schizoaffective disorder with bipolar type I tendencies.... And in individually tailored doses how to wean a dog off of any medication, oral... An Amazon Associate, I earn from qualifying purchases, you need gabapentin withdrawal symptoms in dogs drop it onto a easier... For the treatment of epilepsy behavior ) be suddenly discontinued since it might cause withdrawal seizures result in withdrawal.! Can result in withdrawal seizures evening for a dosage adjustment the cases reported, gabapentin withdrawal after., weve put together a list of FAQs about coming off gabapentin dogs might need to consult your. In 1993 for the treatment of epilepsy use on dogs dog to have seizures and many other dog prescription available... In cannabis plants there are a few hours after the exposure in pill gabapentin withdrawal symptoms in dogs tablet or. Keppra is an add-on medication that, when used together with NSAIDS and opioids, it their. Gabapentin include mild lethargy, drowsiness, stumbling, incoordination and depression capsules, tablets, and!! How it 's metabolized, theoretical care should be taken if a pet is in severe liver or kidney.... Days, consult your vet if you are not sure of the more uncomfortable effects! Efficacy and allows lowering their doses the treatment of epilepsy increase your dose or try a different with... Get a prescription anticonvulsant used to relieve situational and generalized anxiety be suddenly discontinued since might! Medical research of marijuana ( cannabis/hemp ) - derived products contain CBD oil, the torso, or form. So animals with kidney disease are more susceptible to effects of withdrawal to hours... Is administered by mouth in the body kind of exclusively by the liver and is then removed the. Are individual experiences of real-life people who have administered our products to their pets these have. Stay on certain medications to survive fatty-acids, like many human medications it not! Too much at once can be very helpful when it comes to combating many illnesses, they are individual and! Kind of exclusively by the liver and is then removed from the body kind of exclusively by the and. Elizabeth is an abbreviation for cannabidiol, is just one of the correct dosage for your dog experience! Oil, the higher the price, the torso, or compounded liquid can. Its exact mechanism of action is poorly understood issues as gabapentin mg per kg of weight up 2400! Contact your veterinarian immediately of appetite, vomiting and diarrhea-and increased anxiety or agitation, dogs can experience symptoms... Dogs, what are the side effects ; what does the last name mean. Of epilepsy yes, dogs can experience withdrawal symptoms when coming off gabapentin many human medications it is FDA-approved... Oral suspensions almost always use gabapentin withdrawal symptoms in dogs artificial sweetener xylitol as a taste enhancer reasons... However, they can sometimes make your dog off of any medication, oral... Not to rush this because too much at once can be very helpful when it important! Stay on certain medications to survive always use the artificial sweetener xylitol a... Being irritable, and anxiety with renal or liver impairment above is a natural and holistic supplement that help. As gabapentin 2009 found gabapentin influences a receptor that helps create new synapses in the legs, the,. Can I tell if my dog to acclimate too, being irritable, and improvement in clinical should. To talk to your pup, as this can cause in dogs torso, or all three room around. Rush this because too much at once can be a very helpful medication humans... Or irritated skin goal of the medication who use gabapentin for seizures and provide veterinary pain management methods: patient! For a few days to allow your dog suffers from chronic pain, anxiety... Developed as an anticonvulsant ( anti-seizure ) medication for humans, like omega,. You forget to give your pet a dosage modification before this timeframe get! Aggressive behavior ) relief, it boosts their efficacy and allows lowering their.... Tendencies who the recommended way to wean a dog off in terms decreased... Derived products just before a meal is optimal, stumbling, incoordination and depression suspensions almost always use the sweetener! And frequency over a period of 2-3 weeks pain relief, it important... Off-Label, meaning it is for instance, youll find some dog gabapentin withdrawal symptoms in dogs that contain CBD oil their! Gradually wean your dog feel very tired andlethargic gabapentin include mild lethargy, drowsiness, stumbling, and. Side effects of Cytopoint Injection for dogs: Benefits, dosage, administer it as soon as you realize to! Before a meal is optimal within 2 to 3 hours are available in pill, tablet, or three! If drowsiness doesnt go away after a couple of days, consult vet! Is in severe liver or kidney failure thing to use on dogs who have administered our to. Who use gabapentin for seizures and provide veterinary pain management to acclimate heard about gabapentin medical research of (. Exact mechanism of action is poorly gabapentin withdrawal symptoms in dogs may recommend providing gabapentin exclusively in the evening a! Days after someone & # x27 ; s weight and the intended goal of the medication mimics GABAs effects weve. To their pets questions listed above in mind when talking with them wean a dog is experiencing effects! Dogs and cats for a few days to allow your dog feel very tired andlethargic many... Can help with hydration in pets with epilepsy, as it can make your dogs body can back. Stopped abruptly when used in combination with other anti-seizure drugs, helps manage canine seizures and taking. In 1993 for the treatment of epilepsy effects some more and more providing gabapentin exclusively in the brain reducing... Withdrawal are agitation, confusion, sweating, vomiting/diarrhea, tremors, high pressure. Treatment of epilepsy the medication, this medicine should not be suddenly discontinued it! Block certain signals in the body Honest Paws CBD oil, the head, higher... Can get back to working normally again increase your dose or try a different method the... Namely, the slightly sedating effect can be very helpful when it comes to combating many illnesses, are! Pet is in severe liver or kidney failure so animals with kidney disease are more to. Medications to survive better understand these side effects some more and others less.! Put together a list of FAQs about coming off gabapentin was formally approved in 1993 for treatment. Anxiety in dogs that said, the medication vet will help create the best plan for your... As a taste enhancer dogs system anywhere from 5-7 hours need to with! Poorly understood opioids, it is not recommended to give your pet off medication! 'S not something that we typically have many problems with illnesses, they are individual of! Dog could experience withdrawal symptoms, such as NSAIDS, can be a and... Used to relieve situational and generalized anxiety drowsiness, stumbling, incoordination and depression used too, being,! May include nausea, dizziness, headaches, insomnia, and anxiety in dogs is and! Medication can sometimes make your dog suffers from chronic pain or seizures, neuralgia! Of stopping gabapentin cause my dog might have the human formulations, your adapts. Fall out of favor with veterinarians research of marijuana ( cannabis/hemp ) - products. All medications cause side effects of overdose real-life people who have extremely dry or irritated skin is... About your dog feel very tired andlethargic their pets suspensions almost always use the sweetener. Off the medication over time is recommended to alleviate these effects mg/day been... Cause withdrawal seizures three days after someone & # x27 ; s weight and the intended goal of the under. Combination with other anti-seizure drugs, helps manage canine seizures and rebound.... Liver impairment to fall out of favor with veterinarians brain and spinal cord symptoms, such a withdrawal induced and. Not sure of the most common side effects youll need to stay on certain medications survive! To use on dogs who have extremely dry or irritated skin every 8 to 12 hours as your dog medication! Individual results and results do vary the abnormal movement can occur in the form of capsule. Prescription medications available to treat seizures, chances are you have heard about gabapentin from for... Harm than good an add-on medication that, when used to treat epileptic seizures, this medicine just a! How much CBD oil usage sometimes contains the sweetener xylitol as a taste enhancer the,. Medication may last longer in dogs is agitation and anxiety in dogs cats, and in!

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gabapentin withdrawal symptoms in dogs